Topic: RNA in situ hybridization

In neuroscience, progress in understanding brain function, pathologies and neuroanatomy are often interdependent. Forebrain and cortical brain regions are mostly defined, however, midbrain to hindbrain regions are not as well characterized. Earlier this century, we discovered a structure at the transition between the midbrain to hindbrain regions, in rats, that we named the tail of the ventral tegmental area (tTVA), also known as the rostromedial tegmental nucleus (RMTg). The tVTA is now thought to be the primary inhibitory center of midbrain dopaminergic systems, inhibiting dopamine neurons o

The circadian system regulates the timing of multiple molecular, physiological, metabolic, and behavioral phenomena. In Drosophila as in other species, most of the research on how the timekeeping system in the brain controls timing of behavioral outputs has been conducted in males, or sex was not included as a biological variable. The main circadian pacemaker neurons in Drosophila, the small ventral lateral neurons (s-LNvs), also known as M-cells, release the neuropeptide Pigment Dispersing Factor (PDF), which functions as a key synchronizing factor in the network with complex effects on other