Topic: rotarod task

Neonatal hypoxic ischemia (HI) causes motor impairment affecting daily activity. Rehabilitation is frequently implemented to improve motor performance, but its effects are often insufficient for acquiring fine motor coordination. Recently, myelin plasticity has been pointed out necessary for improving motor skills. However, the significance of myelination for motor improvement after HI remains unclear.To address this issue, we investigated the effect of rehabilitation exercise on myelination in a neonatal HI rat model. We then examined the effectiveness of pharmacological promotion of myelinat

Ketosis is a physiological metabolic state, in which fat is the primary energy source (vs glucose), and can be induced through fasting or ketogenic diets (KDs). KDs are rich in lipids and low in carbohydrates, are popular, however, limited literature exists on their safety during pregnancy. Given the essential role of glycolysis in axonal growth dynamics, we hypothesized that KD might disrupt proper axonal guidance during embryonic development, leading to alterations in brain connectivity.Thus, we placed pregnant mice on either a KD or a control diet (CD), starting from gestational day 8.5. KD

The classical model of basal ganglia (BG) network emphasizes a functional organization centered around the striatum and subthalamic nucleus as the main receiving areas of excitatory cortical inputs. However, recent anatomical studies revealed direct input projections from the cortex to the external globus pallidus (GPe) in many species including humans, suggesting that GPe also provides an entry for cortical information to the BG. When and how top-down cortical control of GPe takes place to support motor and cognitive functions remain an open question. Using an optogenetic approach, we first e