Topic: Rotarod test

Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by dopaminergic neuronal damage. We evaluated the neuroprotective effect of γ-amino butyric acid (GABA) in PD and the underlying mechanism focusing on WNT/β-catenin signaling mediated by the MAPK pathway. We treated MPTP-induced SH-SY5Y cells with GABA Low and High concentrations, and we also treated PD model mice with GABA. GABA treatment effectively reduced the expression of biomarkers associated with PD, particularly lewy’s bodies and α-synuclein, and increased the number of tyrosine hydroxylase positive cells. G

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and caudoputamen (Cp), leading to motor and non-motor symptoms. Neuroinflammation, oxidative stress, and imbalance in purinergic signaling significantly contribute to its progression. Current treatments fail to halt disease progression, necessitating novel approaches. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in alleviating PD symptoms, but its underlying mechanisms remain unclear. We investigated the effects of prolonged intermitten

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive loss of substantia nigra dopaminergic neurons, leading to dopaminergic deafferentation of the striatum and invalidating motor symptoms. Several studies suggest that doxycycline (DOX), an old antibiotic from the tetracycline family, could be a neuroprotective drug candidate for PD (Bortolanza et al, J Neural Transm, 2018). Its antibiotic activity may, however, preclude chronic use in patients. Therefore, we have developed a non-antibiotic derivative of DOX referred to as DDOX (12a-deoxy-dedimethylamino-DOX),

The tottering mouse, which harbors a mutation in the CACNA1A gene encoding a P/Q-type voltage-gated calcium channel, serves as a robust tool in neuroscience research for investigating Epilepsy and Episodic Ataxia Type 2 (EA2). In this study, we characterized the tottering mouse phenotype by leveraging ex vivo (loose-cell) and in vivo (extracellular) electrophysiology recordings of Purkinje cells (PCs) within the cerebellum, along with behavioral tests. Our findings reveal that tottering mice display increased irregularity in action potential (AP) firing of PCs without a change in frequency, bu