Topic: S100β

Glioblastoma multiforme is the most common and aggressive malignant brain tumor in adults. One of the factors contributing to the progression is the complex tumor microenvironment. Specially, the coexistence of two cell types, tumoral cells and resident astrocytes, sharing genetic and phenotypical backgrounds. This aspect hinders the phenotypical and functional distinction of both cell types during tumor development. Here, we found a differential expression of the astrocytic markers GFAP and S100β that allowed us to histologically distinguish between tumoral cells and resident astrocytes in GB

Amyotrophic Lateral Sclerosis (ALS), is a neurodegenerative disorder characterised by the progressive and rapid loss of upper and lower motor neurons within the central nervous system. ALS exhibits significant heterogeneity, demonstrating variability in clinical presentation, disease progression, and the neural populations affected. This diversity has historically complicated identifying disease mechanisms and devising universally effective treatments. Organoids derived from patient pluripotent stem cells offer an innovative platform to investigate ALS, by recapitulating the multicellular comp