Topic: SAMP8

​Alzheimer’s Disease (AD) is a progressive brain disorder known to be the most common type of dementia in aging population, yet therapeutical curative approaches remain unmet. Epigenetics is one of the many factors that contribute to the development of the disease, and it is considered a potential therapeutical target on the search of novel pharmacological drugs. Particularly, N6-methyladenosine (m6A) RNA methylation has been shown to be one of the main dynamically reversible epigenetic modifications contributing to the progression of neural degeneration. This way, abnormal levels of m6A have

The circadian rhythm and sleep architecture of senescence-accelerated mice (SAM)P8 and SAMR1 were evaluated to utilize SAM as a model of age-related sleep disorders. The evaluation of the circadian rhythm based on the locomotor activity was performed from 1 to 5 months old SAMP8 and SAMR1. At 6 months of age, mice were chronically implanted with electroencephalograph and electromyogram electrodes for polysomnographic recording of sleep-wake states. The vigilance states were automatically classified by SleepSign ver.3 software. First, the circadian rhythm was evaluated. Comparing the locomotor