Topic: SATB2

Drug addiction poses a significant public health challenge, impacting individuals and societies at large. While substantial progress has been made in understanding the neurobiological underpinnings of addiction, certain aspects remain unresolved. Satb2 is a DNA-binding protein involved in gene expression regulation through chromatin remodelling. We propose that it can emerge as a potential player in addiction mechanisms. A Satb2 conditional mutant (cKo) (Satb2 flox/flox::Camk2a-cre) that was generated showed impairment in long-term memory and an absence of this gene in the Cortex and CA1 regio

Retinal ganglion cells (RGCs) transmit visual information from the retina to the brain and are conserved among vertebrates. In zebrafish, RGCs project their axons to downstream brain areas known as arborization fields (AFs). Previous anatomical studies have demonstrated that each RGC axon targets one or a few of AF1-9 and 10 distinct layers of AF10 (optic tectum). Although it was proposed that each projection type represents one functional type, the correspondence between morphology and function of genetically defined RGC subtypes is still unclear. To address this question, we focused on RGC s

SATB2, encoding a DNA-binding nuclear protein, is genetically associated with human intelligence and schizophrenia. Individuals with SATB2 haploinsufficiency suffer from SATB2-associated syndrome defined by developmental delay, severe intellectual disability, and absent/limited speech. In a previous study we have identified epigenetic profiles and higher-order chromatin interactions that depend on SATB2 in cortical pyramidal neurons of the mouse by integrating high-resolution, multidimensional datasets from Satb2 conditional knockout (cKO) and floxed mice. With remarkable specificity, SATB2-me

The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and accessibility in control versus SATB2-deficient cortical neurons. We find that SATB2 affects the chromatin looping between enhancers and promoters of neuronal-activity-regulated genes, thus influencing their expression. It also alters A/B compartments, topologically associating domains, and frequently interacting regions. Genes linked to SATB2-dependent 3D genome changes are implicated in highly specialized neuronal fu