Topic: Schaffer collateral

The metabotropic glutamate receptor, mGlu5, plays a critical role in the persistency of hippocampal long-term potentiation (LTP), long-term depression (LTD) as well as hippocampus-dependent associative learning and memory (doi: 10.3390/cells11213352). Although well-studied, the majority of investigations as to the role of mGlu5 in these processes in rodents has been done during the light cycle that amounts to the resting phase of rodent species. Sleep-states are regulated by mGlu5 (doi: 10.3390/cells12131761) suggesting that its contribution to hippocampal information processing and storage ma

Depression affects 20% of the general population and is a leading cause of disability worldwide, with one third of patients presenting treatment-resistant depression (TRD). Subanesthetic ketamine is a promising rapid-acting TRD pharmacotherapy, but optimal treatment frequency remains unclear. The present study aims to better understand the effects of an acute (single dose) and chronic (one week daily) 10mg/kg ketamine treatment on hippocampal plasticity, a key mechanism impaired in depression, in a putative TRD model: the Wistar-Kyoto (WKY) rat exposed to chronic mild stress (CMS). Rats were e