Topic: Schedule-Induced Polydipsia

Compulsive behavior, observed in several neuropsychopathological disorders, reflects a deficiency in inhibitory control. This inability to cease actions is associated with abnormal activation and plasticity in the Frontal Cortex (FC). Perineuronal nets (PNNs), which enwrap the cell-body and proximal dendrites of neurons, have been proposed as a candidate mechanism for modulating neuroplasticity. We investigated the changes in activation (cFos expression) and in plasticity (PNN expression) in different regions of the FC through immunolabeling and confocal microscopy in rats selected as high or

Compulsivity denotes the incapacity to discontinue a persisting behavior that has become inappropriate for the prevailing circumstances. Clinical research indicates a comorbidity between alcohol use disorder and obsessive-compulsive symptomatology, leading to a pattern of compulsive alcohol consumption. Thus, compulsivity may be a vulnerability factor contributing to loss of control and alcohol abuse. The aim of the current study was to assess compulsive alcohol drinking and its implication as a determinant for the development of pathological gambling and social violence in both sexes. To acco