Topic: selective plane illumination microscopy

Auditory processing is widely understood to occur differently in autism, though the exact brain activity underlying these differences is not well understood. The diversity of autism also means there may be multiple ways the network can change to produce a similar behavioural output. We used larval zebrafish to investigate auditory habituation in four genetic models of autism: fmr1, mecp2, scn1lab and cntnap2. Larval zebrafish are optically transparent, enabling whole-brain imaging of neural activity at single-cell resolution using genetically encoded calcium indicator GCaMP6s. In free-swimming

An animal’s behavioral state is reflected in the dynamics of population activity and its capacity to process sensory information. Previous studies in mammalian brains have demonstrated a relationship between behavioral states and information processing (Lee et al., 2016, 2019, 2020). However, these studies have been limited to exploring how population dynamics and sensory representation changes in specific cortical areas. Thanks to its transparency at early life stage and the advent of selective plane illumination microscopy, the zebrafish brain is an attractive model that allow for whole brai