Topic: sensory gating

Voluntary movement in animal is regulated be the sensorimotor cortex. The cortex generates the motor command as well as signals to increase the weight of relevant sensory information (sensory gating) that are both essential for the realization of adapted and coordinated movements. The corticospinal tract (CST) is the most direct pathway conveying these signals. Our previous work on anesthetized mice has shown that the lumbar projecting CST induces mainly the modulation of sensory information rather than the direct control of muscle contraction. The aim of our study is to identify the implicati

P50 suppression is a sensory gating phenomenon where the EEG response to the second out of two auditory clicks is decreased in amplitude. Clinical studies have reported the magnitude of P50 suppression to be impaired in schizophrenia. Here, we used a network model of multicompartmental neurons to explore the mechanisms of P50 suppression deficits in schizophrenia. The model consisted of a population of pyramidal neurons interconnected with two interneuron populations: large basket cells and neurogliaform cells, where the latter activates GABAB-receptor mediated post-synaptic currents in its ta