Topic: sensory maps

Primary sensory cortices are functionally organized according to topographic principles, such as the tonotopic map of auditory cortex. Recently, chronic recordings of neuronal activity have revealed that single cell stimulus tuning can undergo continuous remodeling, which appears to be in conflict with the stability of sensory maps. Using longitudinal two-photon imaging in the auditory cortex of 12 mice (21.506 neurons), we attempt to reconcile the conflicting observations of unstable single-cell tuning properties and stable population-level topographic maps. Using intrinsic imaging and chroni

Proprioception enables an organism to sense the position and motion of its limbs and body in space. Comparative evolutionary studies have proposed that the organization of the proprioceptive cortex does not emerge as a consequence of innervation density but rather as a result of the actual use of a limb. We tested this hypothesis by quantifying if and how the proprioceptive cortical representation reorganizes after skilled motor training in adult mice as well as enriched environmental exposure during development.We performed wide-filed calcium imaging of cortical activation in response to mult