Sensory pathways

The structure of neural circuitry plays a crucial role in brain function. Previous studies of brain organization generally had to trade off between coarse descriptions at a large scale and fine descriptions on a small scale. Researchers have now reconstructed tens to hundreds of thousands of neurons at synaptic resolution, enabling investigations into the interplay between global, modular organization, and cell type-specific wiring. Analyzing data of this scale, however, presents unique challenges. To address this problem we applied novel community detection methods to analyze the synapse-leve

The organization of neural circuitry plays a role in brain function. Investigations into this organization have generally had to trade off between coarse descriptions at a large scale and fine descriptions on a very small scale, due to the constraints of the tools and data processing methods available. Recently, reconstructions of tens to hundreds of thousands of neurons at synaptic resolution have been published, enabling investigations into the interplay between global, modular organization, and cell type-specific wiring. Analysis of these enormous data sets requires the development of new m

How our senses work both separately and together involves rich computational problems. I will discuss the spatial and representational problems faced by the visual and auditory system, focusing on two issues. 1. How does the brain correct for discrepancies in the visual and auditory spatial reference frames? I will describe our recent discovery of a novel type of otoacoustic emission, the eye movement related eardrum oscillation, or EMREO (Gruters et al, PNAS 2018). 2. How does the brain encode more than one stimulus at a time? I will discuss evidence for neural time-division multiplexi

Animals exhibit extraordinary variation in their behavior, yet little is known about the neural mechanisms that generate this diversity. My lab has been taking advantage of the rapid diversification of male courtship behaviors in Drosophila to glean insight into how evolution shapes the nervous system to generate species-specific behaviors. By translating neurogenetic tools from D. melanogaster to closely related Drosophila species, we have begun to directly compare the homologous neural circuits and pinpoint sites of adaptive change. Across species, P1 neurons serve as a conserved node in reg

Animals exhibit extraordinary variation in their behaviour, yet little is known about the neural mechanisms that generate this diversity. My lab has been taking advantage of the rapid diversification of male courtship behaviours in Drosophila to gain insight into how evolution shapes the nervous system to generate species-specific behaviours. By translating neurogenetic tools from D. melanogaster to closely related Drosophila species, we have begun to directly compare the homologous neural circuits and pinpoint sites of adaptive change. Across species, P1 interneurons serve as a conserved and