Topic: sEPSCs

Recently, several disorders of the central nervous system (CNS), including Alzheimer's disease (AD) and neuroinflammation have been associated with dysfunction of the neurovascular unit (NVU). As a result, there is an increased demand for therapeutic tools able to act at the NVU. We studied liposomes functionalized with apolipoprotein-E and phosphatidic acid (mApoE-PA-LIP), previously used to promote Aβ removal across the blood-brain barrier (BBB) in an in vivo model of AD, with memory improvement. We performed calcium imaging to study ATP-evoked intracellular Ca2+ waves in hCMEC/D3 and in ast

Secondary progressive multiple sclerosis (SPMS) is an autoimmune neurodegenerative disease characterized not only by white matter compromission, but also by synaptopathy in the grey matter. This lead to an unbalanced Glutamatergic/GABAergic transmission mediated by T lymphocytes infiltration. Here, we explore the possible synaptoprotective effects of Siponimod, a sphingosine 1-phosphate receptor (S1PR) modulator, demonstrated to reduce the accumulation of disability and grey matter damage in SPMS patients.Chimeric experiments were performed by incubating human T cells on murine (C57BL/6) corti