Topic: sepsis

Investigate immune regulation in sepsis, particularly neuroimmune and interorgan communication, using computational analyses of bulk and single-cell sequencing datasets. The project is funded by FAPESP and is expected to start in November 2026. The advertisement lists 31 October 2026 as its application deadline and states that review starts immediately and continues until the position is filled. Submit a CV, research-interest cover letter and contact details for two references to the investigator listed on the official page.

Sepsis is a life-threatening organ dysfunction caused by an exacerbated inflammatory response to an infection. This multifactorial syndrome includes loss of hemodynamic coherence, increasing permeability and blood-brain-barrier breakdown, neuronal death, etc. The presence of cognitive deficits increases mortality. It is defined as sepsis-associated encephalopathy (SAE). Glial cells, such as astrocytes, and mostly the microglia, coordinate the immune response in the brain and are indispensable to SAE pathophysiology. This response occurs through cell signaling via cytokines, such as chemokine C