Topic: Sequential neural activity

The nervous system must perceive and learn durations to guide adaptive behavior. Prior work to investigate the neural substrates of interval timing has focused largely on relatively simple timing tasks whereby subjects learn to discriminate and reproduce the duration of events occurring at a single fixed interval. Although episodic memory requires accurate temporal coding and is mediated by structures in the medial temporal lobe (MTL), including the medial entorhinal cortex (MEC), a well-established role for MTL circuits in interval timing behavior is conspicuously lacking. MEC seems well-suit

Sequential neural activity is hypothesized to underlie driven motor actions, memories of linked sequences of causal relationships, planning and reflection on navigation through environments, and the tracking of the passage of time, among other brain functions. Sequences arise in recurrent networks with asymmetric connectivity structures [1]. These models are of particular interest because they can be learned with biologically plausible temporal asymmetric Hebbian learning (TAH) rules, providing a foundation for modeling of sequential activity in neural circuits. In existing models, the time in