Topic: serial reversal learning

Behavioral flexibility enables us to tailor actions to the ever-changing demands and constraints of our environment. Different regions of the prefrontal cortex, such as the orbitofrontal cortex (OFC) and the medial prefrontal cortex (mPFC), are known to be differentially involved; yet, their complementary roles in behavioral flexibility remain unclear. In order to dissect their relative contributions, we developed a reversal learning task using Freibox, a custom-built, open-source platform for behavioral experiments. Reversal learning performance in this task depends on the OFC, which we demon

Cognitive flexibility, the capacity to adjust thoughts and actions in response to sudden changes in environment, situation, or task demands, is essential for a healthy daily life and for understanding maladaptive behaviors. Reversal learning tasks in animal research are commonly employed to evaluate this adaptability. In particular, serial reversal learning paradigms are useful to assess the ability to switch task-solving strategies. However, conventional serial reversal learning tasks in mice, in general, are time-consuming and labor intensive, limiting its broader application. To address thi