Topic: serotonergic system

ePoster: 2 ePosters

Brain activation patterns during memory processes measured with functional magnetic resonance imaging are associated with human serotonin-1A receptor in vivo

Matej Murgaš, Pavle Mićić, Christian Milz, Andreas Hahn, Rupert Lanzenberger · FENS Forum 2024

The serotonergic system was previously shown to affect learning and memory processes in humans[1]. Establishing a relation between serotonin-1A receptor (5-HT1AR) distribution with memory processing would allow us to further investigate its potential as a therapeutic target. Here, we aim to investigate the effect of 5-HT1AR spatial distribution on the different memory domains. Positron emission tomography data were collected from 20 healthy volunteers using the radioligand [carbonyl-11C]WAY-100635 [2,3]. Data were quantified using multilinear reference tissue model 2 to obtain non-displaceable

ePoster · Neuroscience

Decreased brain serotonin in RBFOX1 mutant zebrafish and partial reversion of behavioural alterations by the SSRI fluoxetine

Maja R. Adel, Ester Antón-Galindo, Edurne Gago-Garcia, Angela Arias-Dimas, Concepció Arenas, Rafael Artuch, Bru Cormand, Noèlia Fernàndez-Castillo · FENS Forum 2024

The splicing factor RBFOX1 exerts a pleiotropic effect on numerous psychiatric and neurodevelopmental disorders; however, the exact working mechanisms remain largely unknown. One potential mechanism that could partially explain the influence of RBFOX1 on some psychiatric traits is through the modulation of the serotonergic system, a common target for medical intervention in psychiatric disorders associated with RBFOX1.Here we studied a rbfox1 mutant zebrafish model, carrying a rbfox1sa15940 allele that expresses a shorter, aberrant rbfox1 mRNA. In the homozygous rbfox1sa15940 zebrafish we obse

ePoster · Neuroscience