Topic: serotonin transporter (SERT)

Neuropsychiatric and neurodevelopmental disorders are a heterogeneous group of mental diseases affecting about 1-billion people worldwide. Common alterations are in the processing of social information, but dedicated pharmacological interventions are missing. Serotonin (5HT) is classically associated with the processing of social information. However, the role of 5HT dynamic, the related circuits and their pharmacological manipulation are still understudied. The serotonin transporter (SERT) re-uptakes 5HT after synaptic release and is widely expressed in the serotonergic terminals projecting t

The Ion AmpliSeqTM was employed for the temporal transcriptomic characterization of the maturation of human stem cell derived neurons at multiple time points. Analysis of the data revealed a progressive increase in markers associated with neuronal development and astrocyte markers over the time. Indicating the establishment of a co-culture containing both glial cells and neurons, and highlighting the importance of culture duration. With the help of unbiased bioinformatics, the top 100 genes driving the principal component analysis clustering and the top 20 differentially expressed genes associ