Topic: SH-SY5Y-derived neurons

Post-traumatic stress disorder (PTSD) is a debilitating stress-related psychiatric disorder that can develop following trauma exposure in some individuals. Among others, it is characterized by a dysregulated hypothalamic – pituitary – adrenal axis, which is predominantly regulated by the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). The neurobiological processes leading to disease remain largely unknown. In vitro models are promising tools to investigate specific neurobiological underpinnings of the stress response in the brain. Here, we investigated the suitability of

Excitotoxicity is a central mechanism in the pathogenesis of different, currently incurable, neurodegenerative diseases. One treatment targeting excitotoxicity is Riluzole (Rilutek®), a drug capable of reducing glutamate release. Currently, Riluzole is available for patients with amyotrophic lateral sclerosis (ALS) to delay the progression of the disease. However, its efficacy diminishes in advanced stages of the pathology.The aim of this study has been to characterize the effect of a novel Riluzole-derived compound (VA945) as a potential neuroprotective drug, aiming at identify a more efficie