Topic: side bias

When making decisions, animals can employ many strategies, from relying on environmental stimuli to relying on internal biases. The roles of cortical regions in shaping these decision-making strategies remain unclear, often because we lack direct access to these internal variables. Here, we investigated how optogenetic inactivation of 29 motor, sensory, or association cortical regions affects decision-making strategies in 20 mice performing a virtual T-maze task in which they were rewarded for choosing the side with more visual cues. To determine mice’s underlying strategies on any trial, we f