Topic: sigma-1 receptor

Aberrant beta-gamma (20-80 Hz) frequency oscillations and impaired cognitive function are reported in schizophrenia patients. Impaired oscillations could be caused by changes in interneuron populations and increased neuroinflammation, as reported in post-mortem studies. Cognitive and network dysfunction can be modelled in rodents using the N-methyl-D-aspartate acid (NMDA) receptor antagonist phencyclidine (PCP). In vivo studies suggest sigma-1 receptor (σ1R) activation may reverse these deficits. We investigated the effect of acute PCP application and σ1R activation on glia and interneurons in