Topic: sigma power

During sleep, memories formed in the hippocampus when awake are progressively transferred to the neocortex, where they are reorganised and stabilised to become long-term memories. This consolidation process is believed to occur concurrently with neuronal oscillations such as sleep spindles. Spindles are waxing-and-waning oscillations in the 10-16 Hz frequency range recorded from the brain's surface, originating in the thalamus and transmitted to the neocortex via thalamo-cortical projections. Several types of spindles have been identified, but how they are linked to specific consolidation proc

The corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator in the central nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CRH modulates key TRN functions, such as sleep spindle rhythmogenesis, has not yet been explored.Using viral mapping, we identified diverse extra-hypothalamic CRH afferents to the TRN, such as the basolateral amygdala, zona incerta and subnuclei within the geniculate nucleus. Combining polysomnographic and photometric recordings in mice, we