Signal propagation

…or "connectome," gives rise to neural signaling and neural function. I will present the first comprehensive brain-wide cell-resolved causal measurements of how neurons signal to one another in response to stimulation in the nematode C. elegans. I will compare this signal propagation atlas to the worm's known connectome to address fundamental questions of structure and function in the brain.

Sensory, cognitive, and motor functions rely on transmission/integration of signals across multiple spatiotemporal scales which are fundamentally constrained by neuroanatomy. Uncovering connectivity patterns that shape signal propagation is thus of central importance to understanding brain computations. An organizational principle of the brain is anatomical/functional hierarchy, often conceptualized as signals propagating up from sensory areas to cognitive areas and down to motor areas. However, to determine if such a hierarchy is a sequential (e.g., MLP) or parallel (e.g., U-net) architecture

…feedback loops that support reliable signal propagation. In this talk, we will address this question by analyzing a large-scale network model of the primate cortex, and we identify a novel dynamical regime termed "interference-free prop

…is how the electrophysiological signals are transmitted is the 3D spatial organization. Many studies ma

…and demonstrate how it controls signal propagation within the thalamocortical system. Then I will show how this cellular-level mechanism provides a natural explanation for why conscious experience