Topic: SIK3

Metabotropic glutamate receptor 2 (mGlu2) is a G protein-coupled receptor expressed in the central nervous system and canonically coupled to Gi/o protein. mGlu2 receptor is the main target of a new generation of antipsychotics which showed unprecedent efficiency on negative and cognitive symptoms of Schizophrenia, which were so far resisting to actual antipsychotics. However, the molecular mechanisms regulating the antipsychotic properties of mGlu2 receptor stimulation remain unclear. In a recent interactomic screen (Philibert et al., Science Advances, 2024), we demonstrated that endogenous mG

In addition to its role in determining sleep need, Salt-inducible kinase 3 (Sik3) is likely to regulate energy homeostasis since mice mutant for exon 13 of the Sik3 gene (Sleepy) display an obese phenotype. The main objective of this project is to identify the role of SIK3 in the central nervous system in the regulation of energy balance. To achieve this, neuron-specific mutant mice lines for the Sleepy gene were generated, as well as viral genetic approaches in Sik3-ex13 floxed mice were used to identify the brain regions involved in SIK3 actions. Our data showed that Vglut2-specific Sleepy m