Topic: single-cell recordings

The ability to reconstruct imagery represented by the brain has the potential to give us an intuitive understanding of what the brain “sees”. Reconstruction of visual input from human fMRI data has garnered significant attention in recent years. Comparatively less focus has been directed towards vision reconstruction from single-cell recordings, despite its potential to provide a more direct measure of the information represented by the brain. Here, we achieve high-quality reconstructions of videos presented to mice, from the activity of neurons in their visual cortex. With our method of video

Orientation selectivity is a prominent feature of neurons in the mammalian primary visual cortex, but there is a dichotomy in the spatial arrangement of these neurons across species. Primates, carnivores and marsupials have orientation-selective neurons organized into structured columns forming two-dimensional maps around pinwheel centers. In contrast, rodents display a seemingly random "salt-and-pepper" organization. The evolutionary versus the environmental basis of this distinction remains unclear. Using intrinsic imaging and massed single-cell recordings, we investigated the organization o