Topic: single nuclei RNA-seq

Understanding the striatal neuronal diversity is key to decipher the basal ganglia circuit and to untangle the complex neurological and psychiatric diseases affecting this brain structure. Two main neuronal groups are found in the dorsal striatum: the abundant medium size projecting neurons (MSNs) and the local neurons or interneurons. While recent studies in the mouse striatum employing advanced technologies have unveiled a significantly broader spectrum of neuronal subtypes, it remains unclear how this diversity extends to the human brain. Here, we conducted single nuclei RNA-seq (snRNA-seq)