Temporal evolution of glial cell phenotype in the midbrain and striatum of A53T-alpha-synuclein transgenic mice: New disease-related mechanisms?
Michele Tufano, Giulia De Riso, Maria Jose Sisalli, Elena D'Apolito, Sergio Cocozza, Davide Viggiano, Antonella Scorziello · FENS Forum 2024
Astrocytes are essential for brain health. Indeed, they provide structural and metabolic support; regulate synaptic transmission; maintain glutamate homeostasis as well as produce neurotrophic molecules. In Parkinson’s disease (PD) these pathways became progressively dysfunctional thus switching to a neurotoxic phenotype. Scientific evidence suggests that neurotoxic glial cells might be responsible for neuroinflammation that plays a key role in the symptoms and development of PD. However, the mechanistic correlation among glial activation, neuroinflammatory response, dopaminergic neuronal loss
ePoster · Neuroscience