Skeletal muscle

…genomics analysis of human and mouse skeletal muscle. Research examines communication between vascular endothelial populations and neighbouring cells, including its disruption in disease. Responsibilities include cell-type annotation, integration of transcriptomic and other omics data, cross-species comparisons, CRISPR-screen analysis, cell-communication and metabolic modelling, and reproducible analysis pipelines. The role works closely with experimental researchers and contributes visualisation, ma

Human organ systems evolved in the context of regular, low- to moderate-intensity endurance physical activity (PA); therefore, our physiology is adapted to relatively high levels of PA. Consequently, chronic inactivity may be a causative factor in the development of non-communicable diseases, including those associated with cognitive decline. Structured, planned exercise, a subcategory of PA, could offset the decline of activity levels in modern societies, however, neither the attributes of effective exercise regimens nor the underlying mechanisms are well determined. It has been suggested tha