Topic: slow wave activity

The analysis of neuronal ensembles often suffers from low spiking activity. As statistical analysis relies on sufficiently large samples, rare joint events in neuronal ensembles usually fail to reach statistical significance. We show that statistical power can be enhanced considerably by careful preselection of specific, separated temporal stripes distributed throughout the whole time series in which spiking is more likely to occur. In a data set of two-photon calcium imaging from the visual cortex of mice (Cleppien et al., 2024+), we identified short temporal stripes of interest from the un

Background: In temporal lobe epilepsy, seizures tend to occur at preferential times of the day. This timing of seizures may result from the sleep-wake history (process S) and/or from the circadian rhythm (process C). We aimed at disentangling their contributions to timing limbic seizures in the hippocampal kainic acid mouse model. Methods: Using 16 depth-electrodes, we recorded limbic seizures in epileptic mice (n=24) exposed to different chronobiological paradigms over months: 1)12h:12h light-dark cycle (LD), 2) gentle sleep deprivation (GSD), 3) continuous dim red light (DD), 4) continuous l