Topic: SNX27

Maintaining the delicate balance between excitatory and inhibitory synaptic activity is crucial for proper brain function. The endosomal trafficking complex, retromer, plays a pivotal role in synaptic function by regulating the post-endocytic sorting of a variety of integral proteins at both excitatory and inhibitory synapses. As a result, SNX27/retromer is emerging as a potential mediator of excitatory/inhibitory crosstalk. In surface proteomic screens from primary cultured neurons, we have shown that a variety of subunits of γ-aminobutyric acid receptors (GABAARs) exhibit reduced surface exp

Sorting Nexin 27 (SNX27) is a hippocampal-enriched endosome-associated cargo adaptor that shapes endocytic events underlying neuronal function and excitability, being relevant for cognitive and reward-associated processes. There is an association of SNX27 with glutamatergic and dopaminergic signaling, as SNX27 modulation alters hippocampal glutamatergic transmission and dopaminergic neurons GABABR-activated GIRK signaling. Notwithstanding, the impact of SNX27 modulation on neuronal circuitry function or behavior remains elusive. In this work we deleted SNX27 in different neuronal types in orde