Topic: social interaction deficits

Early life stress (ELS) has profound and enduring effects on neurodevelopment and social functioning, contributing to the risk of neurodevelopmental disorders. The interleukin-1 receptor (IL-1R1) in the hippocampus plays a pivotal role in mediating the impact of stress on social behavior. However, the involvement of neuronal IL-1R1 (nIL-1R1) in ELS-induced social deficits remains poorly understood. This study aims to address this gap by utilizing a maternal separation (MS) paradigm and innovative cell-type-specific IL-1R1-expressing mouse lines to elucidate the role of nIL-1R1 in MS-induced lo

Autism Spectrum Disorders (ASD) is a multifactorial neurodevelopmental pathology, resulting from a combination of genetic and environmental factors. However, the contribution of each of these two components to the onset and/or the evolution of ASD remains undetermined. Hence the aim of our research project is to evaluate the impact of an in utero exposure to a cocktail of fungicide residues at a European regulatory dose on the brain development of a well-established ASD model, the CNTNAP2 gene-deficient mouse. In order to determine whether the chronic exposure to fungicide might increase the s