Topic: somatostatin-expressing interneurons

The circuitry underlying the initiation, maintenance, and coordination of wakefulness, rapid eye movement sleep, and non-rapid eye movement sleep is not thoroughly understood. Sleep is thought to arise due to decreased activity in the ascending reticular arousal system, which originates in the brainstem and awakens the thalamus and cortex during wakefulness. Despite the conventional association of sleep-wake states with hippocampal rhythms, the mutual influence of the hippocampal formation in regulating vigilance states has been largely neglected. Here, we focus on the subiculum, the main outp

Neuropsychiatric and neurodevelopmental disorders are a heterogeneous group of mental diseases affecting about 1-billion people worldwide. Common alterations are in the processing of social information, but dedicated pharmacological interventions are missing. Serotonin (5HT) is classically associated with the processing of social information. However, the role of 5HT dynamic, the related circuits and their pharmacological manipulation are still understudied. The serotonin transporter (SERT) re-uptakes 5HT after synaptic release and is widely expressed in the serotonergic terminals projecting t