Topic: somatostatin-positive interneurons

Approximately 25% of all cortical neurons are inhibitory interneurons, with somatostatin-positive interneurons (SST+ interneurons) representing a distinct subtype expressing both somatostatin and GABA. These cells form synapses with pyramidal neurons and other interneurons, crucial for modulating cortical information processing and maintaining excitation/inhibition balance. Originating from the medial ganglionic eminence, SST+ interneurons follow a tangential pathway to the cortex, making them susceptible to gene mutations affecting neuronal migration. One such gene, Platelet-activating factor

Memory consolidation is an essential process for our everyday lives. Memory representations are initially encoded in the hippocampus before being consolidated in the neocortex by synaptic plasticity processes that depend on protein synthesis. Within prefrontal cortex (PFC), inhibitory interneurons are critical in gating incoming hippocampal inputs and shaping pyramidal neuron responses. However, how molecular pathways affect synaptic signaling during memory consolidation is unclear. We hypothesize that mechanistic Target Of Rapamycin Complex 1 (mTORC1), a central regulator of protein synthesis