Topic: SOX9

With the prospect of better translation compared to mouse systems, human IPSC-derived neuronal networks are a promising model system to overcome the valley of death in cognitive drug discovery for neurodegenerative disease. Synapse strengthening may prevent or reverse neurodegeneration. However, screening for compounds that achieve this requires a network capable of synapse strengthening and weakening that is supported by human astrocytes and microglia, i.e. a fully human model system of a minimal brain circuit.So far, convincing post-synaptic immunostains of hIPSC-derived neurons are rare, as

During mammalian cortical development, how different subtypes of projection neurons are generated by neural stem cells remains a major challenge. Over recent years, the expansion of RNA sequencing technologies has allowed the identification of heterogeneity within the progenitor pool. Understanding how this heterogeneity could participate in the control of cortical fate commitment is an exciting task. Here, we use single-cell RNA sequencing to describe the molecular characteristics of a subpopulation of RGCs that present reduced neurogenic behavior at early embryonic ages to later produce most