Topic: spasticity

Spasticity is motor dysfunction after Spinal cord injury (SCI). Current treatments of spasticity focusing on muscle contraction have some issues (Figure.1). Phospholipase D coupled metabotropic receptor expresses in Ia fiber endings in muscle spindle and enhances Ia fiber activity. Dihydroxyphenyl glycine (DHPG) work as the antagonist of it. We hypothesized that inhibition of Ia fiber activity using DHPG reduce spasticity. Aim of this study is to confirm effect of continuous inhibition of Ia fiber activity on spasticity symptom and Ia-α connection after SCI. SCI models were made by semi-transe

Leg paresis, loss of coordination, and spasticity often manifest as gait dysfunction in patients with Multiple Sclerosis (MS). Here, we assessed the immediate effects of lumbar transcutaneous spinal cord stimulation (tSCS) in a sham-controlled pilot-study of 26 patients with primary or secondary progressive MS.The study protocol included motor assessments before and after application of tSCS. Stimulation electrodes were positioned on the lumbar spine to activate sensory afferents from the legs. All patients conducted a therapy and a sham condition on two separate study days. Stimulation protoc

Spasticity, characterized by increased spinal stretch reflexes, appears after a certain period following stroke and it is impaired sever skilled movement by spasticity. The mechanism in the cerebral neuronal circuitry is still largely unknown. This present study focused changing of neuronal activity on the ventral medullary reticular nucleus (MdV), which has been recognized as the region associated with skilled movement. Quantitative activation-induced manganese-enhanced MRI is noninvasive measurement of the history of neuronal activity. Manganese ions (Mn2+) enter and accumulate in active neu