Topic: spatial genomics

The Allen Institute has launched a new moonshot initiative on human brain health and disease called the Brain Health accelerator. This initiative aims to dramatically accelerate our understanding of human brain structure and function, identify the molecular, cellular and circuit basis of disease progression, and pioneer new therapeutic strategies targeting vulnerable and affected cell types. Our mission focuses on taking a human-centric approach to understanding and treating disease, combining a large-scale open science discovery approach across multiple diseases, AI-based disease modeling, an

The Laboratory of Exercise and Health seeks a bioinformatician to lead single-cell and spatial genomics analysis of human and mouse skeletal muscle. Research examines communication between vascular endothelial populations and neighbouring cells, including its disruption in disease. Responsibilities include cell-type annotation, integration of transcriptomic and other omics data, cross-species comparisons, CRISPR-screen analysis, cell-communication and metabolic modelling, and reproducible analysis pipelines. The role works closely with experimental researchers and contributes visualisation, ma

The advent of next generation sequencing ushered in a ten-year period of exuberant technology development, enabling the quantification of gene expression and epigenetic features within individual cells, and within intact tissue sections. In this seminar, I will outline our technological contributions, beginning with the development of Drop-seq, a method for high-throughput single cell analysis, followed by the development of Slide-seq, a technique for measuring genome-wide expression at 10 micron spatial resolution. Using a combination of these techniques, we recently constructed a compreh