Topic: spatial memory task

The spatial coding in the hippocampus (HPC) and its emergence during learning is well studied, but it is still unclear how the spatial information in the medial prefrontal cortex(mPFC) is changing between different learning stages. We recorded multiple unit activity using a combination of 24 movable tetrodes for the HPC and a Neuropixels silicon probe with 384 channels for the mPFC. We monitored the formation of spatial representations in both regions while the rat performed a spatial memory task on the radial eight-arm maze. The animal started in the center of the 8-arm maze and needed to loc

The ability to learn new spatial memories is thought to depend on the plasticity of neural circuits in the hippocampus, whose progressive degradation in Alzheimer’s disease (AD) leads to severe cognitive impairments. While decades of in vitro studies indicate that astrocytes regulate various forms of neuronal synaptic plasticity, how the interplay between hippocampal astrocytes and neurons underlies spatial memory in vivo remains unknown, as does its potential link to AD's pathogenesis.To address these challenges, we developed a spatial memory task where mice, tracked with DeepLabCut automated