ePoster · Behavioral Neuroscience
LOU/c/Jall rat as a resilience model in the context of sporadic Alzheimer’s disease induced by streptozotocin
Lucas Gephine, Emna Marouane, Stacy Largillière, Sophie Corvaisier, Thomas Freret, Marianne Leger · FENS Forum 2024
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by early decline in episodic and spatial memory, associated with accumulation of brain markers. Intriguingly, despite similar levels of brain alteration, some elderly subjects show less cognitive impairment than others. To explain this lack of correlation between the degree of brain lesions and the severity of cognitive symptoms, the concept of cognitive resilience (CR) has emerged. Yet, the protective mechanisms supporting CR remain poorly understood. To tackle this issue, we developed a preclinical model of