Topic: spike time tiling coefficient

Microelectrode array (MEA) recordings from human induced pluripotent stem cell (iPSC)-derived neurons show disease-related phenotypes including differences in firing and burst rates. To reveal microscale network activity, we investigated age-related differences in the functional connectivity and network topology. We cultured human neurogenin 2 (NGN2) iPSC-derived neurons with human astrocytes on 64-electrode MEAs (n=15 cultures). We performed 10-minute recordings weekly from days-in-vitro (DIV) 14-35 and analysis with MEA-NAP (https://github.com/SAND-Lab/MEA-NAP/). We applied one-way ANOVA and

In studying connectome organization, generative network models (GNM) have become a critical tool in describing the underlying resource and network constraints driving development. While GNMs highlight nuanced economic trade-offs, they exclusively describe binary networks, without regard for the strength of connections. Weighted generative models (WGM), provide a promising expansion to the current strategy. By leveraging communicability and redundancy calculations, WGMs can modulate edge values within a network throughout development and successfully capture the topology of a biological weighte