Structure-function relationships and extended critical region in modular spiking model
Marianna Angiolelli, Silvia Scarpetta, Pierpaolo Sorrentino, Emahnuel Troisi Lopez, Mario Quarantelli, Carmine Granata, Giuseppe Sorrentino, Vincenzo Palmieri, Giovanni Messuti, Mattia Stefano, Simonetta Filippi, Christian Cherubini, Alessandro Loppini, Letizia Chiodo · Bernstein Conference 2024
Healthy brains exhibit a rich dynamical repertoire with flexible and varied spatiotemporal patterns replays on both microscopic and large scales. Neurodegenerative diseases reduce this functional repertoire. We hypothesize that microscopic dynamics must operate in or near a critical regime for the functional repertoire to be fully explored and for realistic flexible dynamics to emerge. To test this hypothesis, we use a modular Spiking Neuronal Network model, where each group of Leaky Integrate and Fire neurons represents a cortical region. A STDP-based rule is used to learn patterns of activat