Topic: spinal cord contusion

Spinal cord injury (SCI) results in the rupture of blood vessels and bleeding inside the spinal cord, as well as the release of alarmins from necrotic cells, leading to neuroinflammation and disruption of blood-spinal cord barriers. This increased permeability of the blood vessel walls allows for the entry of blood substances into the spinal cord parenchyma. Among these substances is immunoglobulin G (IgG). To understand the role of IgG, we performed immunofluorescence (IF) against IgG at 1 hour, 24 hours, and 7 days post-injury, both near and far from the lesion, in a mouse model of T9-T10 sp

Spinal cord injuries (SCI) are a major health concern, resulting in substantial functional deficits, including vegetative, motor and sensory impairments around and below the affected area. Despite continuous efforts, current spinal cord repair strategies have proven ineffective. The adipose-derived stromal vascular fraction (SVF) contains cells with trophic, pro-angiogenic, and immunomodulatory effects. Our previous study demonstrated that autologous SVF transplantation did not induce endogenous inflammation in SCI rats 14 days after injury. Additionally, it showed the benefits of autologous S