Topic: spinal interneurons

Recent investigations into the coordinated activity of neuronal populations in motor circuits have revealed low-dimensional dynamical features hypothesized to support the generation of patterned motor output. However, such studies have typically relied on vast simplifications - trial-averaging, heavy smoothing - and are often far removed from muscle activity, the true output of the motor system. Thus, it is unclear whether the uncovered dynamical features are primarily useful for intuition-building, or reflect computational mechanisms that operate at the temporal precision of motor control. He

Neural circuits in the spinal cord are composed of diverse sets of interneurons that play a crucial role in shaping motor output. Despite progress in revealing the cellular architecture of the spinal cord, the extent of cell type heterogeneity within cardinal interneuron classes remains unclear, hindering our understanding of the organization of the spinal motor infrastructure. Through a focus on a single cardinal class of spinal interneurons, here we present a comprehensive atlas of V1 interneuron diversity across postnatal development using single-nucleus transcriptomics. We find that cell-t