Topic: Spinocerebellar ataxia type 1

Gait ataxia is one of the most common and impactful consequences of cerebellar dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often involved in the underlying pathology, but their specific functions during locomotor control in health and disease remain obfuscated. We aimed to describe the effect of gradual adult-onset Purkinje cell degeneration on gaiting patterns in mice, and to determine whether two different mechanisms that both lead to Purkinje cell degeneration cause different patterns in the development of gait ataxia. Using the ErasmusLadder together

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease manifested by cerebellar disorders. Alongside cerebellar symptoms, individuals with SCA1 often exhibit a range of ophthalmic abnormalities, particularly those affecting the optic nerve and retina. However, the mechanisms underlying visual disturbances in SCA1 remain unclear.Therefore, in this study, we aimed to analyze the retinal cell layers of mice with SCA1.Sixteen eye samples were obtained from 6-month-old mice (8 from SCA1 mice and 8 from wild-type). The volume of the retina, as well as the volume and