Topic: spontaneous recovery

Early adversities can shape adult behavior, and the early developmental period is an important temporal window for the maturation of brain structures. Potential different phenotypes resulting from environmental modifications during development can eventually impact susceptibility to psychiatric disorders and contribute to the emergence of eating disorders, substance abuse, as well as alter cognitive processes and memory formation. Maternal separation (MS) is a model of early stress that leads to long-lasting changes in the responsiveness of the hypothalamic-pituitary-adrenal axis, as well as b

Ischemic stroke, a major cause of adult disability, results from the blockage of blood flow to the brains, leading to neurological impairments. After a stroke, the neural circuits in the peri-infarct zone undergo plastic changes to allow a spontaneous restoration of the neurological function. However, the extent of spontaneous recovery is highly variable among patients, underscoring the need for neurophysiological biomarkers to predict recovery outcomes and guide treatment strategies. Employing a well-established model of ischemic stroke in mice, the distal middle cerebral artery occlusion (dM