Topic: SPW-Rs

During NREM sleep, the brain is in a self-organized regime in which alternations between spiking and near cessation of spiking propagate along the forebrain, termed slow oscillations (SOs) in the neocortex and SPW-Rs in the hippocampus. Both gain and loss of function studies have demonstrated the importance of tight temporal coordination between SOs and SPW-Rs for systems consolidation, and this temporal coupling has been observed across pairs of regions many synapses removed from one another. However, the spatial extent to which coupling between SPW-Rs and SOs occurs across regions at any one

Sharp wave-ripples (SPW-Rs) are short, high-frequency electrographic events critically involved in learning and memory. In the hippocampus, where SPW-Rs are generated, distinct types of interneurons show diverse activity dynamics during these oscillations. One characteristic behaviour is displayed by TORO cells we recently described, such GABAergic neurons that show particularly robust spiking activity during SPW-Rs but reduced firing during theta activity. The disinhibitory nature of TORO cells raises the question of whether interneurons with opposite behavior also exists. In this study, us

The dorsal midline thalamus (dMT) is a group of non-sensory thalamic nuclei that has been implicated in arousal and in the homeostatic maintenance of sleep choreography. Neocortical slow oscillations and hippocampal sharp wave ripples (SPW-R) are the hallmarks of non-rapid eye-movement (NREM) sleep and reflect synchronous activation of neocortical and hippocampal neuronal ensembles, respectively. The dMT is reciprocally connected both with the neocortex and with the hippocampal system, however, little is known about their interaction during sleep. We performed large-scale unit recordings from