Topic: SST+ neurons

The vibrissae system in rodents, akin to human hands and fingers, facilitates somatosensory information retrieval from individual whiskers during object exploration and recognition. Similar to the enhanced somatosensation in humans with separated digits, the critical ability of mice to sense objects through multiple whiskers in distinct streams is maintained through the precise somatotopic organization in the Brainstem → Thalamus → Cortex axis. This organization results in the formation of barrels and intervening "spaces" known as septa. Our in-vivo silicon probe recordings, conducted simultan

Single-cell methodologies have improved our understanding of cellular diversity within complex tissues such as the mammalian neocortex. However, despite the unprecedented granularity, sampling of minority yet diverse cell populations remains challenging. Here, we show that many subtypes of cortical inhibitory γ-aminobutyric acid-containing (GABAergic) neurons are poorly represented in current atlases, with most datasets limited to adult stages and not recapitulating cell-state transitions of these rare cell types during development. We address this gap by optimizing experimental techniques and