Topic: STAT3

Oligodendrocyte (OL) development undergoes a maturation arrest when premyelinating OL prevalent in preterm fetuses, are exposed to hypoxic injury. Understanding molecular mechanisms controlling OL development may help develop therapeutic strategies in conditions like cerebral palsy. Human fetal neural stem cells (FNSCs) were differentiated into OL and transcriptional changes were analyzed (RNA sequencing). The JAK-STAT cell signaling pathway was implicated in terminal OL maturation. The MO3.13 cell line resembling premyelinating OL was differentiated into mature OL over 7 days, using phorbol 1

After spinal cord injury (SCI), astrocytes become reactive in a process called astrogliosis. These reactive astrocytes surround the lesion and form an astrocyte scar border. Our lab recently previously discovered that LZK (or MAP3K13) regulates reactive astrogliosis and scar formation after a dorsal spinal cord crush injury. The effect of LZK-mediated astrogliosis on neural repair and regeneration is still not clear. We aim to investigate this question utilizing genetically modified mice and RNA sequencing. We are testing the effect of astrocytic LZK overexpression or deletion on behavioral re