Topic: Stimulus novelty

Stimulus novelty modifies perception and promotes exploration and learning. What are the neural circuit mechanisms that underlie the effects of novelty? To address this question, we trained mice on a visual change detection task, while we performed two-photon calcium imaging of neural activity from excitatory and inhibitory (VIP and SST) neuron classes across multiple layers of the visual cortex (areas V1 and LM; 82 mice, 551 sessions, 34,619 neurons). The behavioral task required detecting image changes that occurred amid repeated image presentations. Additionally, flashed images were periodi

Catecholamines play a crucial role in updating mental representations in a world where constant exposure to new information requires continuous adjustments in our actions. To examine how the catecholaminergic system may influence how we structure the continuous stream of information around us into manageable parts, this study makes use of the theory of event segmentation. Building on previous findings, we propose that methylphenidate’s effect on event segmentation behavior depends on learning/prior knowledge and stimulus novelty. In a double-blind, randomized, placebo-controlled crossover stud