Topic: streptozotocin-induced diabetic mice

The trigeminal system plays a crucial role in processing somatosensory information, and its modulation is crucial for maintaining sensory homeostasis. This study investigates the inhibitory modulation of trigeminal somatosensory responses by the locus coeruleus (LC), a key brainstem nucleus that plays a critical role in many cognitive and physiological functions. Previous electrophysiological investigations have revealed a diminished ability of the LC to inhibit somatosensory responses in the caudal nucleus of the trigeminal nerve (Sp5C) of diabetic mice. The administration of noradrenaline ag

Diabetic retinopathy (DR), a common complication of diabetes, is a leading cause of blindness among working-age individuals worldwide. Traditionally, DR was considered primarily a microvascular complication, categorized as either nonproliferative or proliferative based on neovascularization presence. However, emerging evidence suggested that neurodegeneration plays a crucial role in DR beyond its microvascular aspects. Neurotrophic factors, such as nerve growth factor (NGF), have significant effects on neuronal survival. In the visual system, NGF influences retina and optic nerve development,