Topic: stress susceptibility

Stress susceptibility is highly variable among individuals. For those with high stress susceptibility, they have a high risk of developing mental disorders such as depression upon exposure to social stress. Mice also show depression-like behavior following social stress, and the extent of behavioral changes are variable among individuals even under a uniform genetic background. The precise mechanisms that underlie variability in stress resilience among individuals are poorly understood. To elucidate the mechanisms, we focused on the long-term effects of repeated social defeat stress (SDS) in B

Background: Past studies have revealed the lasting effects of stress susceptibility and maternal immune activation on hippocampal DNA methylation landscape in adult offspring. Yet, alterations of the DNA methylation landscape during early postnatal development and following maternal immune activation remain less studied. Methods: We used two mouse strains characterized by social dominance (Dom) and submissiveness (Sub), exhibiting inherent traits of elevated and diminished stress sensitivity. Additionally, Poly IC was administered to a subgroup of the dams at gestational day 14 to induce mater

Parkinson’s disease (PD) is the secondary neurodegenerative disease around the world, affecting more than 6,5 million people. This disease is characterized by a myriad of motor and non motor dysfunctions that worsen over time. Until now, the disease etiology remains unclear, partly because existing PD animal models fail to mimick the physiopathology. Based on the administration of a pathogenic protein (alpha-synuclein) playing a key role in PD, a mouse model has recently been developed at Clinatec (CEA Grenoble) presenting chronic and progressive symptoms that aggravate over time. Neuroprotect

Environmental stress plays a key role in the development of psychiatric disorders, and also has a negative impact on sleep integrity. Insomnia and sleep disturbances are core symptoms observed in patients with stress-related disorders. However, stress reactivity is the result of a combination of genetic and environmental influences that ultimately impacts one’s physiology and behavior in a variety of ways. In this project we will focus on stress susceptibility and how it could trigger psychiatric diseases in a peculiar gene-environment interaction.Studying glutamatergic neurotransmission, we d

Sorting Nexin 27 (SNX27) is a brain-enriched endosome-associated cargo adaptor crucial for cognitive and reward processing and implicated in various neurological conditions. However, its precise role in the nervous system remains elusive. We conducted comprehensive behavioral characterization of SNX27+/- mice, as the KO is not viable, covering motor, cognitive, and emotional aspects. Leveraging recent insights into SNX27's involvement in cellular stress signaling, we also investigated SNX27-stress interplay using a Caenorhabditis elegans Δsnx-27 mutant and wild-type rodents submitted to stress